HPG axis model simulations from Morshead et al 2023 (https://doi.org/10.1016/j.aquatox.2023.106607)

Morshead ML, Jensen KM, Ankley GT, Vliet S, LaLone CA, Aller AV, Watanabe KH, Villeneuve DL. Putative adverse outcome pathway development based on physiological responses of female fathead minnows to model estrogen versus androgen receptor agonists. Aquat Toxicol. 2023 Aug;261:106607. doi: 10.1016/j.aquatox.2023.106607. Epub 2023 Jun 9. PMID: 37354817. R code and data associated with Supplementary Figure 1. Comparison of model-based simulations (n=1000; summarized in box and whisker plot and black points) of Experiment 1 using a computational model of the fathead minnow hypothalamic-pituitary-gonadal axis developed by Li et al. (2011) with empirical results (red triangles).