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46336201.der.pdf
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46336201
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D-amphetamine and chlorpromazine
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51-63-8, 69-09-0
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600091, 600006
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Chivers, S. (2004) Amphetamine Sulphate and Chlorpromazine Hydrochloride: Motor Activity: Positive Control Study in Rat Pups: Final Report. Project Number WR0475. Unpublished study prepared by Central Toxicology Lab. 65 p.
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2004.0
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D-Amphetamine Sulfate and Chlorpromazine Hydrochloride: In a positive control motor activity study in rat pups at 14, 18, and 22 days post partum using the Coulbourn Lab Linc Infra-red Motion Activity System (MRID 6336201), groups of ten Alpk:APfSD (Wistar-derived) rats/sex (1 pup/sex/litter from 30 litters) were exposed to vehicle control (deionized water), 10 mg/kg of d-amphetamine sulfate or 10 mg/kg chlorpromazine hydrochloride on postnatal day 14, 18, or 22 (postnatal day one was the day of birth) in one intraperitoneal dose, and tested one hour later for 50 minutes.
At a dose of 10 mg/kg of amphetamine, male motor activity (total) was decreased on days 14 and 18 compared to controls (26% and 64% of controls, respectively), and was increased to 206% of controls on day 22. In females, activity was 72% and 49% of controls on days 14 and 18, respectively, and 296% of controls on day 22. The effects of D-amphetamine were statistically significantly different from controls in males on days 14 and 22, and females on days 18 and 22. In males on day 18 and females on day 14 there were no significant increases or decreases at any time 5 minute block compared to controls.
At a dose of 10 mg/kg of chlorpromazine, male motor activity (total) was decreased at every testing day for both males and females, but the decreases were not statistically significant for males and females on day 14, and females on day 22. On day 14 motor activity 37% of controls in males and 77% of controls in females; on day 18, motor activity was 38% of controls in males and 18% of controls in females; and on day 22, motor activity was 23% in males and 40% in females of the control levels.
This study is classified Acceptable/Non-guideline. Central Toxicology Laboratory has demonstrated proficiency in this study for detecting changes in motor activity (Coulbourn Lab Linc Infra-red Motion Activity System) due to D-Amphetamine Sulfate and Chlorpromazine Hydrochloride treatments in pre and postnatal Alpk:APfSD (Wistar-derived) rat pups (PNDs 14, 18, 22) for the time period around 2002 (in life period of study). This positive control study does not satisfy any guideline requirement.
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Other
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NA [870.6200, Neurotoxicity screening battery|870.6300, Developmental neurotoxicity study]
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Intraperitoneal
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No Duration Period; Positive Control Study
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54596.0
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2012-03-20
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2017-02-10
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Added by
Madison Feshuk
on Apr 25, 2022
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