46484601.der.pdf

• filename: 46484601.der.pdf
• MRIDs: 46484601
• CHEMICAL_SUBSTANCE_NAME: Scopolamine hydrobromide
• CHEMICAL_CASRN: 114-49-8
• CHEMICAL_PC_CODE: 600094
• STUDY_CITATION: Dent, M. (2005) Assessment of the Effect of Scopolamine on Morris Water Maze Learning, and Assessment of Auditory Startle Response Habituation in Young Rats. Project Number: HLS/248/003159. Unpublished study prepared by Huntingdon Life Sciences, Ltd. 36 p.
• STUDY_YEAR: 2005.0
• EXECUTIVE_SUMMARY: Scopolamine hydrobromide: As part of a series of studies submitted to demonstrate the proficiency of Huntingdon Life Sciences, Ltd., Cambridgeshire, England to perform neurotoxicology and neuropathology tests on male and female Crl:CD® (SD) IGS BR rats, learning and memory (MRID 46484601) were assessed in groups of 10 rats/sex/dose using a Morris water maze. Scopolamine was administered on day 23±2 of age at doses of 0, 0.5, 1.0, or 1.5 mg/kg/day by intraperitoneal injection 20 minutes before testing on four consecutive days. Clinical signs and necropsy findings were not reported. All animals appeared to gain weight normally during the four days of testing. Males and females of all treated groups had significantly (p ¿ 0.05 or 0.01) longer swimming times, greater numbers of failed trials, and more sector entries than did the controls. The number of animals in each treated group with at least one failed trial did not decrease appreciably with successive testing days. No dose-response was evident as all treated groups responded similarly. This study is classified Acceptable/Nonguideline. Huntingdon Life Sciences, Ltd. has demonstrated proficiency in this study for detecting changes in Morris water maze test due to Scopolamine treatment in postweaning (PND 23-26) Crl:CD® (SD) IGS BR rats for the time period around 2003 (in life period of study). This positive control study does not satisfy any guideline requirement. The auditory startle phase was not reported due to equipment problems.
• STUDY_TYPE: Other
• GUIDELINE_COMMENT: NA [870.6300, Developmental neurotoxicity study]
• ADMIN_ROUTE: Oral
• DOSE_PERIOD: No Duration Period; Neurobehavioral (auditory startle response and learning and memory) positive control data
• txr: 53777.0
• memoDate: 2012-03-20
• UpdateDate: 2016-09-07
• Comments:

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