Supp Files and Code for Paul Friedman et al., "Reproducibility of organ-level effects in repeat dose animal studies"

Supplemental File 1 contains the datasets used in MLR for estimation of variance. Supplemental File 2 contains tabular reporting of input data for concordance analysis and results as percent concordance observed by chemical-endpoint, chemical-endpoint-species, and chemical-endpoint-study type combinations. Supplemental File 3 contains MLR study descriptors and results for quantitative estimates of variance. Supplemental File 4 contains odds ratio datasets and results. Supplemental File 5 contains summarized LEL and HED values, ToxCast assay endpoint information, and calculated AED50 values using library(httk) v2.2.2. Supplemental File 6 contains the R code used for this analysis and figures in this work, available as a knitted R Markdown file (exported as html). The code (performed with R version 4.2.1). Supplemental File 7 contains Supplemental Figures 1, 2, and 3.